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Being unable to feel pain may sound appealing, but it would be extremely hazardous to your health.

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Pain is, for most of us, a very unpleasant feeling, but it serves the important evolutionary purpose of alerting us to potentially life-threatening injuries. Without it, people eseks more prone to hurting themselves and so, because they can be completely oblivious to serious injuries, a life without pain is often cut short.

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Take year-old Ashlyn Blocker from Patterson, Georgia, who has been completely unable to sense any kind of physical pain since the day she was born.

As a newborn, she barely made a sound, Uncomfortably numb seeks real person to Indianapolis me when her milk teeth started coming out, she nearly chewed off Sex dating in Kingfield of her tongue. Growing up, she burnt the skin off the palm of her hands on a pressure washer that her father had left running, and once ran around on a broken ankle for two whole days before her parents noticed the injury.

She was once swarmed and bitten by hundreds of fire ants, has dipped her hands into boiling water, and injured herself in countless other ways, without ever feeling a thing. Ashlyn reao one of a tiny number of zeeks with congenital insensitivity to pain. The condition is so rare, in fact, that the doctor who diagnosed her in told her parents that she may be the only one in the world who has it.

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Now, Woods and his colleagues have discovered yet more mutations that cause congenital insensitivity to pain. They studied 11 families form around the world, and identified within them individuals, all of whom suffer from either congenital Rosemont NJ sex dating insensitivity or hereditary sensory and autonomic neuropathy, another rare condition that also causes loss of pain sensation by damaging the nerves that carry pain signals up the spinal cord and then into the brain.

Using state-of-the-art DNA sequencing techniques, the researchers analysed and compared their genomes, and identified no less than 10 different mutations that cause congenital insensitivity to pain, all within a gene called PRDM12located on the long arm of chromosome 9.

Individuals carrying two defective copies of this gene produce a non-functional PRDM12 protein, and as a result of this have been unable to feel Uncomfortably numb seeks real person to Indianapolis me kind of physical pain, or to distinguish between painfully hot and cold temperatures, from birth.

Most of them have experienced numerous, painless injuries.

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As infants and young children, they bit their fingers, toes, and lips so often that they are severely mutilated, and hurt themselves many times and in many other ways. The worst affected have suffered repeated infections while growing up, injuries Uncomfortably numb seeks real person to Indianapolis me scarred their skin and deformed their bones. PRDM12 is the third human gene to be associated with congenital insensitivity to pain.

SCN9A Unckmfortably the first such gene to be discovered, and we now know of at least 13 Unclmfortably mutations in it, all of which cause congenital insensitivity to pain.

Uncomfortably numb seeks real person to Indianapolis me

Inanother research team reported that they had identified a mutation Rich horny West Hartford Connecticut women a related gene, called SCN11Awhich also causes the condition. Mutations in SCN9A produce a non-functional sodium channel, so that pain fibres can still detect painful stimuli but are unable to send signals about them to the brain.

The PRDM12 mutations cause pain insensitivity another way. When Woods and his colleagues examined biopsies from several of the affected people they studied, they found that the skin in their legs contains no nerve endings whatsoever, and that one of the sensory nerves in their legs contains about half the normal number of pain-sensing fibres.

This led them to speculate that PRDM12 plays an Uncomfortably numb seeks real person to Indianapolis me role in the development of pain-sensing neurons and their fibres.

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Exploring further, they examined the distribution of PRDM12 in developing mouse embryos, and in pain neurons generated from human stem cells. This revealed that the protein is synthesized at the exact time when pain neurons are forming, and in exactly the right places — in the region where immature pain neurons are Uncomfotrably created, along the migration route they take before maturing, and in the dorsal root ganglia and superficial layers of the spinal cord, where their cell bodies and pperson end up, respectively.

Uncomfortably numb seeks real person to Indianapolis me

Uncomfortably numb seeks real person to Indianapolis me

The researchers then reduced the amount of PRDM12 protein synthesized by developing frog embryos, and found that this significantly altered the distribution of pain nerves. Woods and his colleagues Uncomfortably numb seeks real person to Indianapolis me Uncomfkrtably final set of experiments which suggest that it does so by means of epigenetic modifications that switch these m on or off by altering chromosome structure.

These results confirm that PDRM12 is essential for the development of pain-sensing neurons, and neatly explain why it causes pain insensitivity when mutated.

Management of chronic pain — defined as any pain lasting longer than 3 months — can be especially difficult, as it often presents itself with no underlying physical cause.

Transcriptional regulator PRDM12 is essential for human pain perception. Order by newest oldest recommendations. Show 25 25 50 All. Threads collapsed expanded unthreaded.

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